Publications

2020

Templeman, N.M., Cota, V., Keyes, W., Kaletsky, R., and Murphy, C.T. (2020). CREB non-autonomously controls reproductive aging through Hedgehog/Patched signaling. Developmental Cell 54(1): 92-105.

Botezelli, J.D., Overby, P., Lindo, L., Wang, S., Haïda, O., Lim, G.E., Templeman, N.M., Pauli, J.R., and Johnson, J.D.(2020). Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice. American Journal of Physiology—Endocrinology and Metabolism 319: E529–E539.

2018

Templeman, N.M., Luo, S., Kaletsky, R., Shi, C., Ashraf, J., Keyes, W., and Murphy, C.T. (2018). Insulin signaling regulates oocyte quality maintenance with age via cathepsin B activity. Current Biology 28(5): 753–760.

Templeman, N.M., and Murphy, C.T. (2018). Regulation of reproduction and longevity by nutrient-sensing pathways. Journal of Cell Biology 217(1): 93–106.

2017

Templeman, N.M., Flibotte, S., Chik, J.H.L., Sinha, S., Lim, G.E., Foster, L.J., Nislow, C., and Johnson, J.D. (2017). Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan. Cell Reports 20:451–463.

Templeman, N.M., Skovsø, S., Page, M.M., Lim, G.E., and Johnson, J.D. (2017). A causal role for hyperinsulinemia in obesity. Journal of Endocrinology 232(3): R173–R183.

2016

Templeman, N.M., Mehran, A.E., and Johnson, J.D. (2016). Hyper-variability in circulating insulin, high fat feeding outcomes, and effects of reducing Ins2 dosage in male Ins1-null mice in a specific pathogen-free facility. PLOS ONE 11(4): e0153280.

Dionne, D.A., Skovsø, S., Templeman, N.M., Clee, S.M., and Johnson, J.D. (2016). Caloric restriction paradoxically increases adiposity in mice with genetically reduced insulin. Endocrinology 157(7): 2724-2734.

2015

Templeman, N.M., Clee, S.M., and Johnson, J.D. (2015). Suppression of hyperinsulinemia in growing female mice provides long-term protection against obesity. Diabetologia 58(10): 2392-2402.

2014

Templeman, N.M., Leblanc, S., Perry, S.F., and Currie, S. (2014). Linking physiological and cellular responses to thermal stress: β-adrenergic blockade reduces the heat shock response in fish. Journal of Comparative Physiology B 184(6): 719–728.

2012

Mehran, A.E., Templeman, N.M., Brigidi, G.S., Lim, G.E., Chu, K.Y., Hu, X., Botezelli, J.D., Asadi, A., Hoffman, B.G., Kieffer, T.J., Bamji, S.X., Clee, S.M., and Johnson, J.D. (2012). Hyperinsulinemia drives diet-induced obesity independently of brain insulin production. Cell Metabolism 16(6): 723–737.

Templeman, N.M., Schutz, H., Garland, T., and McClelland, G.B. (2012). Do mice selectively bred for high locomotor activity have a greater reliance on lipids to power submaximal aerobic exercise? American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 303(1): R101-R111.

2010

Templeman, N.M., Beaudry, J.L., Le Moine, C.M.R., and McClelland, G.B. (2010). Chronic hypoxia- and cold-induced changes in cardiac enzyme and gene expression in CD-1 mice. Biochimica et Biophysica Acta 1800(12): 1248-1255.

2009

Currie, S., Bagatto, B., DeMille, M., Learner, A., LeBlanc, D., Marks, C., Ong, K., Parker, J., Templeman, N.M., Tufts, B.L., and Wright, P.A. (2009). Metabolism, nitrogen excretion, and heat shock proteins in the central mudminnow (Umbra limi), a facultative air-breathing fish living in a variable environment. Canadian Journal of Zoology 88(1): 43-58.